![]() ![]() Structural, morphological, and compositional properties were investigated by the physicochemical characterization method.Through the green bio-synthesis method the gold-silver core-shell nanoparticles (Au-Ag NPs) synthesised by Garcinia mangostana crude peels extract as a reducing and stabilising agents.These findings suggest that Au-AgNPs system can be used as a potent nanocarrier to combat cancerous cells by offering additional anticancer properties to the loaded drug. The PCA-loaded Au-AgNPs also showed a better selectivity towards HCT116 compared to CCD112 colon normal cells when tested at the same concentrations. Up to 80% inhibition of HCT116 cells was observed after the treatment of PCA-loaded Au-AgNPs at 15.63 μg/ml. In HCT116 colon cancer cells, PCA-loaded Au-AgNPs (IC 50 = 10.78 μg/ml) showed higher inhibitory action than the free PCA (IC 50= 148.09 μg/ml) and Au-AgNPs alone (IC 50= 24.36 μg/ml). Plant-based drug, protocatechuic acid (PCA) was loaded on the Au-AgNPs to investigate their anticancer activity. The size of Au-AgNPs was 38.22 ± 8.41 nm and was mostly spherical in shape. A complete coating was observed through transmission electron microscopy (TEM) when the ratio of AuNPs and AgNPs was 1:9. Gold-silver core-shell nanoparticles (Au-AgNPs) were synthesized through seed germination process in which gold nanoparticles acted as the seed. This study aimed to synthesize core-shell nanoparticles via green method which utilised crude peels extract of Garcinia mangostana as reducing and stabilising agents for drug delivery. Core-shell nanoparticles have emerged as good candidate for anticancer treatment. Hence, there is an urgent need to discover a more target-specific therapeutic agent to overcome this problem. Current treatment and anticancer drugs cannot specifically target the cancerous cells, thus causing toxicity towards surrounding non-cancer cells. ![]() 4School of Medicine, Institute of Virology, Technical University of Munich, Munich, GermanyĬolorectal cancer is one of the most killing cancers and this has become a global problem.3Department of Medical Sciences, School of Medical and Life Sciences (SMLS), Sunway University, Jalan Universiti, Bandar Sunway, Selangor Darul Ehsan, Malaysia.2School of Materials Science, Japan Advanced Institute of Science and Technology (JAIST), Nomi, Japan.1Malaysia-Japan International Institute of Technology (MJIIT), Universiti Teknologi Malaysia, Kuala Lumpur, Malaysia.Kar Xin Lee 1, Kamyar Shameli 1*, Yuki Nagao 2, Yen Pin Yew 1, Sin-Yeang Teow 3 and Hassan Moeini 4*
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